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Current methodologies and data analysis techniques in vibrational spectroscopy and their biomedical applications

As with many other spectroscopic techniques, Raman and infrared spectroscopy have made great progress due to recent developments in optics, detectors, nanotechnology, and computer science. There is increasing interest in the biomedical field in using these methods for diagnostic and in vivo applications. For example, explorative and rapid analysis techniques can be used to diagnose disease or dysfunction via infrared or Raman spectral fingerprints.

This comprehensive overview of biomedical applications of vibrational spectroscopy focuses on methodologies that are most relevant to biodiagnostics. After a few introductory chapters that summarize the current status of the field, the reference covers three primary areas:

• Current spectroscopic applications suitable for routine use in cytology,histopathology, and clinical chemistry
• New spectroscopic directions providing increased analytical sensitivity or spatial resolution that make them suitable for in vivo and in situ applications such as resonant Raman scattering, CARS, SERS, and PTIR
• Study design and the analysis of vibrational spectral fingerprints from complex biological and clinical samples

With chapters contributed by leading international experts, Biomedical Vibrational Spectroscopy is a core resource for chemists, biologists, and clinical researchers working at research institutes, universities, hospitals, and pharmaceutical companies, as well as professionals and researchers in biophysics, biomedicine, bioinformatics, and clinical and analytical chemistry.

About the Author

PETER LASCH, PhD, is a Research Scientist with the Robert Koch Institute in Berlin, Germany, and a specialist in FTIR spectroscopy and its applications to the biomedical field.

JANINA KNEIPP, PhD, is an Assistant Professor in the Chemistry Department of Humboldt University, Berlin. Drs. Lasch and Kneipp have authored and coauthored numerous peer-reviewed articles in the field of biomedical infrared and Raman spectroscopy.